منابع مشابه
Expanding Phenotype of Fetal Hydantoin
subsequent birth of normal children occur frequently enough to be frustrating for those involved in the evaluation of malformed children and counseling of the parents. The fetal hydantoin syndrome, while a recognizable pattern of malformation in some patients,2 is not such a well defined entity as, for example, achondroplasia or Down syndrome is. It is not uncommon for one to see a child with s...
متن کاملThe hydrolysis of hydantoin by various tissues.
In 1912 Lewis (1) administered hydantoin to rabbits, cats, and dogs and came to the conclusion that the ring was not readily broken in the body. Gaebler and Keltch (2) some years later showed that some hydantoin was excreted as hydantoic acid after injection into dogs. Wada (3) claimed that urea was produced from hydantoin after incubation with milk or certain tissue suspensions. Finally, Kozel...
متن کاملThe hydantoin transport protein from Microbacterium liquefaciens.
The gene hyuP from Microbacterium liquefaciens AJ 3912 with an added His6 tag was cloned into the expression plasmid pTTQ18 in an Escherichia coli host strain. The transformed E. coli showed transport of radioisotope-labeled 5-substituted hydantoins with apparent K(m) values in the micromolar range. This activity exhibited a pH optimum of 6.6 and was inhibited by dinitrophenol, indicating the r...
متن کاملConformationally restricted TRH analogs: a probe for the pyroglutamate region.
In principle, the development of the active analog approach to computer-assisted drug design can offer a unique opportunity for dramatically increasing the efficiency of designing new drug candidates by predicting the biologically active conformation of peptide ligands.1 But how do we know that such molecular modeling predictions are accurate, and can a specific set of chemical probes be develo...
متن کاملThe Bacteroidetes Q-Rule: Pyroglutamate in Signal Peptidase I Substrates
Bacteroidetes feature prominently in the human microbiome, as major colonizers of the gut and clinically relevant pathogens elsewhere. Here, we reveal a new Bacteroidetes specific feature in the otherwise widely conserved Sec/SPI (Sec translocase/signal peptidase I) pathway. In Bacteroidetes, but not the entire FCB group or related phyla, signal peptide cleavage exposes N-terminal glutamine res...
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ژورنال
عنوان ژورنال: European Journal of Organic Chemistry
سال: 2018
ISSN: 1434-193X
DOI: 10.1002/ejoc.201800986